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Pitaya Reserch

Research Article

Wound healing properties of Hylocereus undatus on diabetic rats

R. M. Perez G. 1 *, R. Vargas S. 2, Y. D. Ortiz H. 2

1Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias extractivas IPN, Punto fijo 16, col. Torres Lindavista cp 07708, Mexico
2Laboratorio de Investigacion de Fitofarmacología, Universidad Autónoma Metropolitana-Xochimilco A.P. 48-231 México D.F.

email: R. M. Perez G. (

*Correspondence to R. M. Perez G., Punto Fijo No. 16, Col. Torres de Lindavista C.P. 07708 Mexico, D.F. Mexico.


Aqueous extracts of leaves, rind, fruit pulp and flowers of Hylocereus undatus were studied for their wound healing properties. Wound healing effects were studied on incision (skin breaking strength), excision (percent wound contraction) and the nature of wound granulation tissues, which were removed on day 7 and the collagen, hexosamine, total proteins and DNA contents were determined, in addition to the rates of wound contraction and the period of epithelialization. In streptozotocin diabetic rats, where healing is delayed, topical applications of H. undatus produced increases in hydroxyproline, tensile strength, total proteins, DNA collagen content and better epithelization thereby facilitating healing. H. undatus had no hypoglycemic activity. Copyright © 2005 John Wiley & Sons, Ltd.

Received: 21 July 2004; Accepted: 24 May 2005

Digital Object Identifier (DOI)

10.1002/ptr.1724 About DOI

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